Ketotic (idiopathic glucagon unresponsive) hypoglycaemia: diazoxide effects.
نویسنده
چکیده
منابع مشابه
Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.
Two sibs who sustained severe hypoglycaemia in the neonatal period are reported. In spite of treatment with frequent feeds intravenous glucose, glucagon, hydrocortisone, and diazoxide, hypoglycaemia persisted, and both infants eventually required subtotal pancreatectomy. Tests for leucine toleranct were normal though the second case showed some protein sensitivity. Histological and immunohistoc...
متن کاملNesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia.
Three newborn infants are reported who developed severe non-ketotic hypoglycaemia (blood glucose less than 1.1 mmol/l; 19.8 mg/100 ml) within 6 hours of birth. All had inappropriately raised plasma insulin concentrations for the level of glycaemia, and required high rates of glucose infusion (less than 15 mg glucose/kg per minute) to prevent symptoms of hypoglycaemia. Medical treatment (hydroco...
متن کاملHyperosmolar non-ketotic hyperglycaemia during oral diazoxide therapy of prolonged hyperglycaemia in infancy.
Diazoxide is a benzothiadiazine derivative, chemically closely related to thiazide diuretics but lacking diuretic activity. Fajans et al (1968) have recorded this agent's ability of supress insulin release from normal and abnormal islet cell tissue. This property was exploited in the treatment of our patient, a 16 week-old infant with severe, prolonged symtomatic hypoglycaemia. Unfortunate adve...
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Effect of ephedrine in ketotic hypoglycaemia. The effect of oral ephedrine administration on a child with ketotic hypoglycaemia who had not responded to dietary measures alone was studied. After ephedrine administration, the hypoglycaemia developing after ketogenic stress was less profound and was substantially delayed. The impaired glycaemic response to glucagon during hypoglycaemia, character...
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The major potential adverse effect of use of sulfonylurea agents (SUAs) is a hyperinsulinaemic state that causes hypoglycaemia. It may be observed during chronic therapeutic dosing, even with very low doses of a SUA, and especially in older patients. It may also result from accidental or intentional poisoning in both diabetic and nondiabetic patients. The traditional approach to SUA-induced hyp...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 47 254 شماره
صفحات -
تاریخ انتشار 1972